产品信息
抗原名称
TRP Channel
商品描述
SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
分子量
367.87
纯度
>98%
可溶性
DMSO : 100 mg/mL (226.87 mM; Need ultrasonic)
H2O : 50 mg/mL (113.43 mM; Need ultrasonic)
H2O : 50 mg/mL (113.43 mM; Need ultrasonic)
外观
Powder
In vitro(体外研究)
SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents.
In vivo(体内研究)
SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
背景
别名
SAR7334 hydrochloride ；TRCP 6 inhibitor
分子式
C21H22ClN3O
CAS号
1333207-63-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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