产品信息
抗原名称
Tryptophan Hydroxylase
商品描述
Telotristat ethyl (LX1032) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
分子量
574.98
纯度
>98%
可溶性
DMSO : ≥ 101.5 mg/mL (176.53 mM)
In vivo(体内研究)
LX1606 (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. LX1606 (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. LX1606 (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation. LX1606 (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But LX1606 (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. LX1606 (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis.
背景
别名
特罗司他乙酯
分子式
C27H26ClF3N6O3
CAS号
1033805-22-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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