S-(5‘-Adenosyl)-L-methionine (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.^1,2,3 SAM (tosylate) (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use.⁴ SAMe reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity.^5,4,6,7,8

≥95%