产品信息
抗原名称
IDH2 R140Q mutant
商品描述
AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM).
分子量
481.5
纯度
>98%
可溶性
DMSO 96 mg/mL (199.37 mM)
Ethanol 96 mg/mL (199.37 mM)
Ethanol 96 mg/mL (199.37 mM)
外观
Powder
In vitro(体外研究)
AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples.
背景
别名
AGI 6780; AGI6780
分子式
C21H18F3N3O3S2
CAS号
1432660-47-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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