Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.^1,2,3 It exerts its activity by binding to five distinct G protein-coupled receptors, S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8.^1,2 W140 is an inactive enantiomer of W146, a selective S1P₁ antagonist (K_i = 77 nM), that binds to the S1P₁ receptor with a K_i of 4.6 µM (2a = W146; 2b = W140 in supplemental material).⁴ It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

≥95%