产品信息
抗原名称
GPCR19
商品描述
INT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM.
分子量
450.65
纯度
98%
可溶性
Ethanol : 50 mg/mL (110.95 mM)
DMSO : 31 mg/mL (68.79 mM)
DMSO : 31 mg/mL (68.79 mM)
In vitro(体外研究)
INT-777 is a novel potent and selective TGR5 agonist with remarkable in vivo activity. INT-777 (3 μM) increases ATP production in the human enteroendocrine cell line NCI-H716 in a cAMP-dependent manner. INT-777 (10 μM) lowers Isc and increases TEER when added on the serosal side of seromuscular stripped distal colon segments. INT-777 effect on basal secretion is reduced in neuron-free and TTX-treated mucosal-submucosal preparations.
In vivo(体内研究)
INT-777 (1 μM/min/kg, p.o.) has a potent choleretic effect, prevents carboxyl CoA activation and subsequent conjugation, thereby favoring its cholehepatic shunt pathway with a ductular absorption and a potent choleretic effect in HF-fed TGR5-Tg male mice. INT-777 (30 mg/kg/day, p.o.) increases energy expenditure and reduces hepatic steatosis and obesity upon high fat feeding, and improves insulin sensitivity, in TGR5-Tg mice.
背景
别名
S-EMCA
分子式
C27H46O5
CAS号
1199796-29-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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