ZINC12613047 is a selective butyrylcholinesterase (BChE) inhibitor with an IC₅₀ value of 21 nM for human BChE versus an IC₅₀ value of 102.1 µM for mouse AChE.¹ At 10 µM, it has been shown to inhibit Aβ_1-42 self-induced aggregation by 61.7% and to protect human neuronal SH-SY5Y cells from Aβ_1-42 peptide toxicity.¹

≥95%