产品信息
抗原名称
mGluR
商品描述
LY341495是II型代谢型谷氨酸受体拮抗剂，对人mGlu2，mGlu3，mGlu8，mGlu7a，mGlu1a，mGlu5a和mGlu4a受体的IC50分别为2.3，1.3，173，990，6800，8200和22000 nM。
分子量
353.37
纯度
98% min
可溶性
10 mM in DMSO
In vivo(体内研究)
LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala in mGluR3-KO mice.
背景
别名
LY 341495; LY-341495
分子式
C20H19NO5
CAS号
201943-63-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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