产品信息
抗原名称
5-HT2A
商品描述
Pimavanserin is a potent and selective serotonin <b>5-HT2A</b> inverse agonist with <b>pIC50</b> of 8.73, used to treat psychosis associated with Parkinson’s disease.
分子量
1005.2
纯度
＞98%
可溶性
DMSO ：100mg/mL(99.48mM)
Water ：100mg/mL(99.48mM)
Ethanol ：100mg/mL(99.48mM)
Water ：100mg/mL(99.48mM)
Ethanol ：100mg/mL(99.48mM)
In vivo(体内研究)
In rats, Pimavanserin (3 mg/kg, p.o.) attenuates DOI-induced head twitches. In mice, Pimavanserin (3 mg/kg, p.o.) significantly attenuates MK-801-induced hyperactivity. In a rat model of parkinsonian tremor, Pimavanserin (40 mg/kg, i.p.) produces a significant overall reduction of tacrine-induced tremulous jaw movements.
背景
别名
Pimavanserin tartrate；ACP-103 tartrate； ACP-103； Nuplazid
分子式
C50H68F2N6O4.C4H6O6
CAS号
706782-28-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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