产品信息
抗原名称
PARP
商品描述
NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
分子量
176.17
纯度
98%
可溶性
1eq. NaOH : 17.6 mg/mL (100 mM)
DMSO : 17.6 mg/mL (100 mM)
DMSO : 17.6 mg/mL (100 mM)
外观
off-white solid
In vitro(体外研究)
NU1025 (0.2 mM) treatment attenuates H2O2 induced cytotoxicity. NU1025 per se does not have any effect on cell viability. NU1025 pretreatment significantly increases cell viability (82.59 ?4.67%) in SIN-1 (0.8 mM) exposed cells. NU1025 has no detectable effect on the proliferation of D54 and U251 cells. Treatment with NU1025 markedly inhibits the enhanced activation of PARP-1 induced by TPT and RT treatment. No DNA strand breakage is detected following exposure to 200 µM NU1025 alone.
In vivo(体内研究)
Treatment with NU1025 (1 and 3 mg/kg) reduces the infarction to 25% and 45% versus vehicle treated rats, respectively. NU1025 (1 and 3 mg/kg) treatment significantly reduces edema volume. NU1025 also produces significant improvement in neurological deficits.
背景
别名
NU 1025
分子式
C9H8N2O2
CAS号
90417-38-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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