产品信息
抗原名称
PPARγ,Androgen Receptor
商品描述
EPI-001 is an <b>androgen receptor</b> N-terminal domain antagonist with <b>IC50</b> of ∼6 μM and a selective <b>PPAR-gamma</b> modulator.
分子量
394.89
纯度
＞98%
可溶性
Ethanol : 70 mg/mL (177.3 mM)
DMSO : 70 mg/mL (177.3 mM)
DMSO : 70 mg/mL (177.3 mM)
外观
A crystalline solid
In vitro(体外研究)
EPI-001 blocks transactivation of the AR NTD, interacts with the AF-1 region, inhibits protein-protein interactions with AR, and reduces AR interaction with androgen-response elements on target genes. In LNCaP cells, EPI-001 inhibits both androgen-dependent and androgen-independent (OCM-induced) cell proliferation. In LNCaP cells, EPI-001 also acts as a PPAR-gamma modulator to result in inhibition of androgen receptor expression and activity, which inhibits prostate cancer growth.
In vivo(体内研究)
In male mice bearing CRPC LNCaP s.c. xenografts, EPI-001 (50 mg/kg, i.v.) blocks the androgen-axis and inhibits androgen-dependent tumor growth by reducing proliferation and increasing apoptosis.
背景
别名
双酚A
分子式
C21H27ClO5
CAS号
227947-06-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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