产品信息
抗原名称
STAT3
商品描述
HO-3867 is a selective STAT3 inhibitor.
分子量
464.55
纯度
>98%
可溶性
DMSO 13 mg/mL warmed (27.98 mM)
Ethanol 6 mg/mL warmed (12.91 mM)
Water slightly soluble or insoluble
Ethanol 6 mg/mL warmed (12.91 mM)
Water slightly soluble or insoluble
In vitro(体外研究)
HO-3867 produces significant cytotoxicity in A2780 and other tested ovarian cancer cell lines, with less toxic to noncancerous ovarian surface epithelial cells. HO-3867 induces G(2)-M cell cycle arrest in A2780 cells and promotes apoptosis by caspase-8 and caspase-3 activation. HO-3867 blocks the JAK/STAT3 pathway in human ovarian cancer cell lines.
In vivo(体内研究)
HO-3867 (100 ppm p.o.) inhibits the growth of ovarian cancer xenograft tumor in mice without any apparent signs of toxicity, and also results in inhibition of pSTAT3 as well as downregulation of the STAT3-targeting proteins. HO-3867 sensitizes cisplatin-resistant ovarian carcinoma through STAT3 inhibition. HO-3867 (100 ppm p.o.) also attenuates left-heart-failure-induced pulmonary hypertension by decreasing oxidative stress and increasing PTEN expression in the lung of rats.
背景
别名
HO3867,HO 3867
分子式
C28H30F2N2O2
CAS号
1172133-28-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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