Pyridostatin-RR 82- trifluoroacetate_1472611-44-1；1085412-37-8(free base)_Absin
产品信息
抗原名称
G-quadruplex
商品描述
Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.
分子量
596.64(free base)
纯度
>98%
可溶性
DMSO 100 mg/mL
Water 100 mg/mL
Ethanol 30 mg/mL
Water 100 mg/mL
Ethanol 30 mg/mL
外观
Powder
In vitro(体外研究)
Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes.
背景
别名
RR82,RR-82,RR 82
分子式
C31H32N8O5.xC2HF3O2
CAS号
1472611-44-1；1085412-37-8(free base)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
本文来自投稿，不代表本人立场，如若转载，请注明出处：http://www.iamyjet.com/article/25237.html