Isca Biochemicals由多肽科学家在英国埃克塞特成立，他们拥有先进的多肽合成设备，并拥有向生命科学界提供高质量定制和目录产品的长期经验。我们的主要业务是定制肽合成，我们还拥有一系列用于生物研究的生化标准和新型研究肽，这是由不断从文献中引入创新产品推动的，其中许多是Isca有的。我们目前提供用于信号转导、疼痛研究、食欲调节、FRET底物、免疫学研究、抗病毒肽、神经肽、蛋白酶试剂、抗菌肽和激酶试剂的研究肽，并且我们的范围不断扩大，我们的产品被各地的研究人员引用，并定期出现在高影响力期刊上。

iscabiochemicalsKS-220

Tat braftide

编号KS-220

结构：

H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Aarg-Pro-Gln-PEG-Thr-Arg-His-Val-Asn-Ile-Leu-Phe-Met-OH

其他名称：

GRKKRRQRPQ-PEG-TRHVNILLFM公司

活动：

变构BRAF抑制剂

Tat-braftide是一种BRAF激酶抑制剂，由10肽抑制剂braftide-TRHVNILLFM组成，由PEG连接到细胞穿透序列Tat。Tat-braftide被设计成与BRAF激酶结构域的二聚体界面结合，因此它通过破坏BRAF二聚体来抑制BRAF蛋白激酶活性，在激酶分析中IC50为43 nM。此外，以BRAF激酶的二聚体界面为靶点导致RAF和MEK的蛋白质降解，揭示了RAF在保护大型MAPK复合物免受蛋白质降解方面的新型支架功能。Tat-braftide在多种显示RAS依赖性或独立性的细胞中显示出对WT-BRAF和BRAFG469A的有效抑制和降解。Tat公司−braftide治疗导致HCT116和HCT-15细胞的生长受到剂量依赖性抑制，EC50值分别为7.1和6.6μM，表明KRAS突变的结肠癌细胞的细胞活力受到了有效抑制。

技术数据

结构H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Aarg-Pro-Gln-PEG-Thr-Arg-His-Val-Asn-Ile-Leu-Phe-Met-OH

分子量2990.47

公式C128H227N51O30S

序列GRKKRRQRRRPQXTRHVNILLFM

修改X=PEG=-NH-CH2-CH2-O-CH2-CH2-O-CH2-CH-C=O-

溶解性和储存

溶解性可溶于水

外观冻干固体

储存干燥、冷冻、避光保存

批次特定数据

hplc测定纯度>95%

iscabiochemicals新增产品列表

2022

October

KS-220 Tat-braftide Allosteric BRAF inhibitor

September

PP-360 SMRwt Disrupts the Nef-mortalin interaction, anti-metastatic

AM-350 Urumin Antiviral host defense peptide

CY-040 rytvela scrambled peptide Scrambled control peptide for rytvela

August

PP-350 PDHPS1 YAP signaling pathway inhibitor

AM-340 KLA peptide Proapoptotic mitochondrial membrane disruptor

RT-030 FGF7p FGF7 mimetic

July

TP-030 TIP TRPV1 inhibitor

PI-290 Multi-Leu peptide PACE4 inhibitor

PP-340 Tat-D3S2 DIRAS3 - beclin1 interaction inhibitor

June

PP-330 RS17 CD47 - SIRPα signalling inhibitor

KS-210 MOTS-c AMPK activator

PP-320 VGN50 Blocks MYC activation

May

PI-270 Compstatin C3 convertase inhibitor

PP-310 Rb4 Induces expression of HMGB1 and calreticulin

PI-280 Q14 USP30 inhibitor

April

CK-030 EPI-X4 Endogenous CXCR4 antagonist

HD-010 SAP15 HDAC5 inhibitor

PP-300 NP-12 PD-1/PD-L1 interaction blocker

March

PP-290 KP1 Disrupts TGF-β/TβR2 interaction

CY-030 rytvela IL-1 receptor allosteric antagonist

OR-030 SHBG141–161 GPRC6A agonist

PP-280 TPP-1 Blocks PD-1/PD-L1 interaction

February

IG-050 Synstatin Syndecan-1 mediated integrin activation inhibitor

NR-180 S9pep SOX9 mimetic

PP-270 TAT-ANK Dll4-Notch1 inhibitor

January

CH-010 Chemerin-9 Chemokine-like receptor 1 (CMKLR1) agonist

PP-260 Tat-NTS peptide Blocks the interaction of ANXA1 with importin β

AS-010 NT1–20 Blocks ASIC1a binding to RIPK1

2021

December

TP-020 SOR-C13 TRPV6 antagonist

AM-330 AMPR-22 Antimicrobial peptide derived from Romo1

FZ-010 Fz7-21 Selective FZD7 antagonist

CY-020 S7 Interleukin-6 inhibitor

November

PR-100 P4pal10 PAR4 antagonist

TP-010 tatM2NX Cell permeable TRPM2 antagonist

CK-020 HBP08 CXCL12/HMGB1 heterocomplex inhibitor

EP-020 SFKEELDKYFKNHTSP Epitope from the S2 protein of SARS-CoV-2

FP-030 Atto647N-LPETGG Sortase reagent

October

FP-040 Atto550-LPETGG Sortase reagent

PP-250 A11 ANXA1–EphA2 interaction blocker

AV-010 F9170 Inactivates HIV-1 virions

PP-240 NFAT Inhibitor Calcineurin-NFAT interaction inhibitor

September

PP-230 Tat-CIRP MD2 - CIRP interaction blocker

CR-020 CRF (human, rat) Endogenous CRF receptoragonist

SP-050 Rad17 derived peptide ATR kinase substrate

OX-050 Orexin A (human, rat, mouse) OX1 and OX2 receptor agonist

OR-020 VPM-p15 GPR64 (ADGRG2) agonist

CY-010 S1H Human growth hormone receptor antagonist

PP-220 F1 Blocks the association of IKKbeta and NEMO

August

PP-210 p28 Binds to p53 and inhibits cop1 binding

GL-040 GIP_HUMAN[22–51] Endogenous proatherosclerotic peptide hormone

AM-320 IDR 1002 Innate defence regulator peptide

PP-200 Tat-beclin 1 Autophagy inducing peptide

AM-310 Pexiganan Broad spectrum antibacterial agent

July

PP-170 Caveolin-1 scaffolding domain peptide The binding domain of caveolin-1

PP-120 (D)-PPA 1 PD-1/PD-L1 interaction inhibitor

PP-040 Tat-βsyn-degron α-Synuclein knockdown peptide

PP-110 Foxy 5 Wnt5a mimetic peptide

PP-030 KSL 128114 Binds the PDZ1 domain of syntenin

June

AM-300 SAAP 148 Antimicrobial peptide derived fromLL-37

AM-290 Pap12-6 Antibacterial derived from the N-terminus of papiliocin

AM-280 BING Antimicrobial peptidefrom Japanese medaka fish