Focusbiomolecules10-1363说明书

目录＃10-1363

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Mitoquinone |线粒体靶向抗氧化剂

Mitoquinone（444890-40-9）是一种靶向线粒体的抗氧化剂。显示心脏和神经保护作用。¹在阿尔茨海默病的小鼠模型中显示有益效果。²Mitoquinone保护胰腺β细胞免受氧化应激并改善胰岛素分泌。³细胞可渗透。

CAS：

444890-41-9

目录编号：

10-1363

活动：

线粒体靶向抗氧化剂

化学名称：

10-（6'-泛醌基）癸基三苯基溴化鏻

分子量：

663.64

分子式：

C₃₇H₄₄BrO₄P.

溶解性：

溶于DMSO。

物理特性：

棕色蜡状固体

纯度：

通过TLC
NMR测定98％（符合）

贮存温度：

-20°

稳定性：

供应稳定3年。DMSO中的溶液可以在-20°下储存长达3个月。

运输代码：

RT

参考文献/引文
1）Ghosh等。（2010），帕金森病模型中线粒体靶向药物的神经保护作用;自由基。生物学。Med。，491674
2）McManus等。（2011），线粒体靶向抗氧化剂MitoQ防止阿尔茨海默病转基因小鼠模型中空间记忆保留和早期神经病理学的丧失;J.Neurosci。，3115703
3）Lim等人。（2011），靶向线粒体的抗氧化剂保护胰腺β细胞免受氧化应激，改善胰岛素分泌的葡萄糖毒性和糖脂毒性;细胞生理学。Biochem。，28873

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