BD Pharmingen- FITC Mouse Anti-Human CD48_BD Pharmingen
产品信息
荧光素标记
FITC
抗原名称
CD48
宿主
Mouse IgM, κ
简单描述
The TÜ145 monoclonal antibody specifically binds to CD48. CD48 belongs to the CD2 family within the immunoglobulin superfamily. CD48 is a ~43 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD48 is strongly expressed on lymphocytes, monocytes and macrophages and weakly on granulocytes. The expression of CD48 is upregulated following lymphocyte activation and by Epstein-Barr virus (EBV) infection. CD48 binds with high affinity to CD244 and with low affinity to CD2. These receptor-ligand interactions can augment or inhibit leukocyte responses.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
商品描述
TÜ145
The TÜ145 monoclonal antibody specifically binds to CD48. CD48 belongs to the CD2 family within the immunoglobulin superfamily. CD48 is a ~43 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD48 is strongly expressed on lymphocytes, monocytes and macrophages and weakly on granulocytes. The expression of CD48 is upregulated following lymphocyte activation and by Epstein-Barr virus (EBV) infection. CD48 binds with high affinity to CD244 and with low affinity to CD2. These receptor-ligand interactions can augment or inhibit leukocyte responses.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
同种型
Mouse IgM, κ
克隆号
克隆 TÜ145 (RUO)
产品详情
FITC
Fluorescein (FITC) is part of the BD blue family of dyes. This is a small organic fluorochrome with an excitation maximum (Ex Max) at 494-nm and an emission maximum (Em Max) at 518-nm. FITC is designed to be excited by the Blue laser (488-nm) and detected using an optical filter centered near 520 nm (e.g., a 530/30-nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.
FITC
Blue 488 nm
494 nm
518 nm
应用
实验应用
Flow cytometry (Routinely Tested)
推荐用量
20 µl
反应种属
Human (QC Testing)
目标/特异性
CD48
背景
别名
BCM1; BLAST; BLAST1; Hulym3; MEM-102; OX45; SLAMF2; TCT.1
制备和贮存
存储溶液
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
文献
文献
研发参考(3)
1. Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:1-1182.
2. Sandrin MS, Mouhtouris E, Vaughan HA, Warren HS, Parish CR. CD48 is a low affinity ligand for human CD2. J Immunol. 1993; 151(9):4606-4613. (Biology).
3. Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995.
参考图片
Profile of peripheral blood lymphocytes analyzed on a FACScan (BDIS, San Jose, CA)
Profile of peripheral blood lymphocytes analyzed on a FACScan (BDIS, San Jose, CA)
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