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BD Pharmingen- Biotin Mouse Anti-Human CD30_BD Pharmingen

艾美捷科技 • 2025年08月26日 17:00:24 • 抗体 • 阅读 40 • 标签
产品信息
抗原名称
CD30
宿主
Mouse IgG1, κ
简单描述
The BerH8 monoclonal antibody specifically binds to CD30, a 120 kDa type I transmembrane glycoprotein expressed on stimulated T and B cells. CD30 is an activation marker initially identified to be expressed on Reed-Sternberg cells. It is also expressed on a few extrafollicular T and B cells located at the rim of germinal centers. CD30 serves as a cytokine receptor. It belongs to the nerve growth factor receptor/tumor necrosis factor receptor (NGFR/TNFR) superfamily and is also known as TNFRSF8. CD30 interaction with CD30 ligand (CD30L/CD153/TNFSF8) can mediate signals for proliferation, apoptosis and cytotoxicity of lymphoid cells.
商品描述
BerH8 The BerH8 monoclonal antibody specifically binds to CD30, a 120 kDa type I transmembrane glycoprotein expressed on stimulated T and B cells. CD30 is an activation marker initially identified to be expressed on Reed-Sternberg cells. It is also expressed on a few extrafollicular T and B cells located at the rim of germinal centers. CD30 serves as a cytokine receptor. It belongs to the nerve growth factor receptor/tumor necrosis factor receptor (NGFR/TNFR) superfamily and is also known as TNFRSF8. CD30 interaction with CD30 ligand (CD30L/CD153/TNFSF8) can mediate signals for proliferation, apoptosis and cytotoxicity of lymphoid cells.
同种型
Mouse IgG1, κ
克隆号
克隆 BerH8 (also known as Ber-H8) (RUO)
浓度
0.5 mg/ml
产品详情
Biotin
Biotin is a ubiquitous co-factor (also known as Vitamin B7) that has many properties that make it extremely useful for molecular biology. Biotin has an extremely high affinity for the Avidin family of proteins (Kd = 10-15 M), making it the perfect tool to link two molecules. Biotin labeled antibodies can be combined with any number of Avidin-conjugated probes in order to customize an assay to a particular need. This is especially useful in the case of magnetic cell separation using streptavidin/magnetic bead conjugates, or in the case of flow cytometry using streptavidin/fluorophore conjugates.
应用
实验应用
Flow cytometry (Routinely Tested)
反应种属
Human (QC Testing)
目标/特异性
CD30
背景
别名
TNFRSF8; TNR8; CD30L/CD153 receptor; Ki-1; D1S166E
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(7) 1. Beverly PCL. Activation antigens: new and previously defined clusters. In: McMichael AJ. A.J. McMichael .. et al., ed. Leucocyte typing III : white cell differentiation antigens. Oxford New York: Oxford University Press; 1987:516-524. 2. Bowen MA, Olsen KJ, Cheng L, Avila D, Podack ER. Functional effects of CD30 on a large granular lymphoma cell line, YT. Inhibition of cytotoxicity, regulation of CD28 and IL-2R, and induction of homotypic aggregation. J Immunol. 1993; 151(11):5896-5906. (Clone-specific). 3. Franke AC, Jung D, Ellis TM. Characterization of the CD30L binding domain on the human CD30 molecule using anti-CD30 antibodies. Hybridoma. 2000; 19(1):43-48. (Biology). 4. Guesdon JL, Ternynck T, Avrameas S. The use of avidin-biotin interaction in immunoenzymatic techniques. J Histochem Cytochem. 1979; 27(8):1131-1139. (Biology). 5. Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:1-1182. 6. Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995. 7. Schwarting R, Stein H. Cluster report CD30. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:419-422.
数据库链接
Entrez-Gene ID
943

参考图片

Flow cytometric analysis of CD30 expression on YT (NK cell line) cells. YT cells were stained with either Biotin Mouse Anti-Human CD30 (Cat. No. 555828; solid line histogram) or Biotin Mouse IgG1, κ Isotype Control (Cat. No. 555747; dashed line histogram), followed by PE Streptavidin (Cat. No. 554061). Fluorescent histograms were derived from gated events with the side and forward light-scattering characteristics of viable cells. Flow cytometery was performed on a BD FACScan™ system.

Flow cytometric analysis of CD30 expression on YT (NK cell line) cells. YT cells were stained with either Biotin Mouse Anti-Human CD30 (Cat. No. 555828; solid line histogram) or Biotin Mouse IgG1, κ Isotype Control (Cat. No. 555747; dashed line histogram), followed by PE Streptavidin (Cat. No. 554061). Fluorescent histograms were derived from gated events with the side and forward light-scattering characteristics of viable cells. Flow cytometery was performed on a BD FACScan™ system.

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