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BD Pharmingen- Purified Mouse Anti-Human CD61_BD Pharmingen

艾美捷科技 • 2025年08月27日 08:37:07 • 抗体 • 阅读 156 • 标签
产品信息
抗原名称
CD61 (Integrin β3)
宿主
Mouse IgG1, κ
简单描述
The VI-PL2 monoclonal antibody specifically binds to CD61. CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion.
商品描述
VI-PL2 The VI-PL2 monoclonal antibody specifically binds to CD61. CD61 is a 105 kDa transmembrane glycoprotein that is also known as integrin β3 and platelet glycoprotein IIIa (GPIIIa or GP3A). It is expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin β3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion.
同种型
Mouse IgG1, κ
克隆号
克隆 VI-PL2 (also known as VIPL2) (RUO)
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested), Immunohistochemistry-frozen, Western blot (Tested During Development)
反应种属
Human (QC Testing), Rhesus,Cynomolgus,Baboon,Dog,Cow (Tested in Development)
目标/特异性
CD61 (Integrin β3)
背景
别名
Integrin β3; Integrin beta-3; GP3A; GPIIIa; ITGB3; ITB3
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(3) 1. Kishimoto T. Tadamitsu Kishimoto .. et al., ed. Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. New York: Garland Pub.; 1997. 2. Mason D. David Mason .. et al., ed. Leucocyte typing VII : white cell differentiation antigens : proceedings of the Seventh International Workshop and Conference held in Harrogate, United Kingdom. Oxford: Oxford University Press; 2002. 3. Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995.

参考图片

Flow cytometric analysis of CD61 expression on human peripheral blood platelets. Platelets were stained with either Purified Mouse Anti-Human CD61 (Cat. No. 555752; solid line histogram) or Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746), followed by FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988). Fluorescent histograms were derived from gated events with the side and forward light-scattering characteristics of viable platelets.

Flow cytometric analysis of CD61 expression on human peripheral blood platelets. Platelets were stained with either Purified Mouse Anti-Human CD61 (Cat. No. 555752; solid line histogram) or Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746), followed by FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988). Fluorescent histograms were derived from gated events with the side and forward light-scattering characteristics of viable platelets.

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