BD Pharmingen- Purified Mouse Anti-Human CD95_BD Pharmingen
产品信息
抗原名称
CD95 (Fas)
宿主
Mouse IgM, κ
简单描述
Reacts with a 45 kD type I membrane molecule also known as APO-1, or Fas antigen. CD95 belongs to the tumor necrosis factor receptor (TNF-R) family of proteins and is expressed on various cells, including activated T cells and B cells. The interaction of CD95, Fas antigen, with Fas ligand is one of the many mechanisms that lead to apoptosis or programmed cell death. The interaction of CD95 expressing target cells with Fas ligand on cytotoxic T cells induces an apoptotic signal leading to target cell death. It has been reported that apoptosis is the mechanism used by the immune system in clonal deletion of self-reactive T cells during embryological development.
商品描述
EOS9.1
Reacts with a 45 kD type I membrane molecule also known as APO-1, or Fas antigen. CD95 belongs to the tumor necrosis factor receptor (TNF-R) family of proteins and is expressed on various cells, including activated T cells and B cells. The interaction of CD95, Fas antigen, with Fas ligand is one of the many mechanisms that lead to apoptosis or programmed cell death. The interaction of CD95 expressing target cells with Fas ligand on cytotoxic T cells induces an apoptotic signal leading to target cell death. It has been reported that apoptosis is the mechanism used by the immune system in clonal deletion of self-reactive T cells during embryological development.
同种型
Mouse IgM, κ
克隆号
克隆 EOS9.1 (RUO)
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested), Fluorescence microscopy, Functional assay (Tested During Development)
反应种属
Human (QC Testing)
目标/特异性
CD95 (Fas)
背景
别名
Fas/APO-1
制备和贮存
存储溶液
Aqueous buffered solution containing no preservative.
保存方式
Aqueous buffered solution containing no preservative.
文献
文献
研发参考(4)
1. Kishimoto T. Tadamitsu Kishimoto .. et al., ed. Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. New York: Garland Pub.; 1997.
2. Krammer PH, Dhein J, Walczak H. The role of APO-1-mediated apoptosis in the immune system. Immunol Rev. 1994; (142):175-191. (Biology).
3. Nagata S, Golstein P. The Fas death factor. Science. 1995; 267(5203):1449-1456. (Biology).
4. Rouvier E, Luciani MF, Golstein P. Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med. 1993; 177(1):195-200. (Biology).
参考图片
Jurkat cells treated for 6 hours with CD95 (EOS9.1)
Jurkat cells treated for 6 hours with mouse IgM isotype control
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