TdT

Reacts with terminal deoxyribonucleotidyltransferase (TdT), a template-independent DNA polymerase that adds nucleotides to single stranded DNA primers. Western blot analysis of TdT reveals bands of 55, 40 and 15 kDa. TdT is found in normal bone marrow lymphoid progenitor cells and immature thymic lymphocytes. It has been reported that TdT is involved in the regulation and/or translocation of DNA and gene rearrangement during normal T and B cell development.

E17-1519

Intracellular staining (flow cytometry) (Routinely Tested)

Human (QC Testing)

TdT

研发参考(3) 1. Fuller SA, Philips A, Coleman MS. Affinity purification and refined structural characterization of terminal deoxynucleotidyltransferase. Biochem J. 1985; 231(1):105-113. (Biology). 2. Keren DF, Hanson CA, Hurtubise PE. David F. Keren, Curtis A. Hanson, Paul E. Hurtubise., ed. Flow cytometry and clinical diagnosis. Chicago: ASCP Press; 1994:1-676. 3. Sasaki R, Yuasa Y, Masuyama A, Takaku F, Bollum FJ. Production of a specific monoclonal antibody to terminal deoxynucleotidyl transferase (TdT) and the extensive studies of TdT in patients with hematological malignancies. 1993; 25(4):223-225. (Biology).