BD Pharmingen- Purified Mouse Anti-Human p16 with Control_BD Pharmingen
产品信息
抗原名称
CDKN2A (p16-INK4a)
简单描述
Cyclins and cyclin-dependent kinases (cdks) form active complexes that regulate key events during the progression of the cell cycle and are evolutionarily highly conserved. The p16 protein has been identified as a specific inhibitor of cdk4 because it blocks cdk4 substrate phosphorylation. p16 inhibits cdk4 dependent phosphorylation of the tumor suppressor retinoblastoma protein (Rb) and Rb related proteins, p107 and p130. The biochemical properties of p16 suggest that it may be a tumor suppressor gene product. Recently a gene cloned from the short arm of human chromosome 9, Multiple Tumor Suppressor 1 (MTS1) has been identified as the gene for p16. The gene, now also known as the CDKN2 gene, has been found to be mutated in a very high percentage of tumors, including 75% of melanoma cell lines.
克隆号
G175-405
BD化合物表
- 描述数量/尺寸零件号EntrezGene ID
- Purified Mouse Anti-Human p1650 µg (1 ea)51-1325GRN/A
- HeLa Control Lysate50 µg (1 ea)51-16516NN/A
应用
实验应用
Western blot (Routinely Tested), Immunohistochemistry-frozen, Immunohistochemistry-paraffin, Immunoprecipitation (Tested During Development)
反应种属
Human (QC Testing)
目标/特异性
p16 INK4A
参考图片
Western blot analysis for p16. HeLa cell lysate (Component No. 51-16516N) was probed with the Mouse Anti-Human p16 antibody (clone G175-405, Component No. 51-1325GR) at concentrations of 0.25 (lane 1), 0.125 (lane 2), and 0.06 µg/ml (lane 3). p16 is identified as a band of 16 kDa.
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