CD8a

Rat LOU, also known as Louvain, LOU/C, LOU/M IgG2a, κ

Mouse Spleen Cells or Thymocyte Membranes

BD IMag™ anti-mouse CD8a Particles - DM are magnetic nanoparticles that have monoclonal antibody conjugated to their surfaces.  These particles are optimized for the positive selection or depletion of CD8a-bearing leukocytes using the BD IMag™ Cell Separation Magnet.  CD8a has been reported to be expressed on most thymocytes and a subpopulation of mature T lymphocytes ( e.g. MHC class I-restricted T cells, including most T suppressor/cytotoxic cells).  In addition, subsets of γδ TCR-bearing T cells, intestinal intraepithelial lymphocytes, and dendritic cells also have been reported to express CD8a.

53-6.7 BD IMag™ anti-mouse CD8a Particles - DM are magnetic nanoparticles that have monoclonal antibody conjugated to their surfaces.  These particles are optimized for the positive selection or depletion of CD8a-bearing leukocytes using the BD IMag™ Cell Separation Magnet.  CD8a has been reported to be expressed on most thymocytes and a subpopulation of mature T lymphocytes ( e.g. MHC class I-restricted T cells, including most T suppressor/cytotoxic cells).  In addition, subsets of γδ TCR-bearing T cells, intestinal intraepithelial lymphocytes, and dendritic cells also have been reported to express CD8a.

Rat LOU, also known as Louvain, LOU/C, LOU/M IgG2a, κ

克隆 53-6.7 (RUO)

Cell separation (Routinely Tested)

CD8a

Cd8a; CD8 alpha chain; Ly-2; Lyt2; Lyt-2; Ly-35; Ly-B

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

研发参考(10) 1. LeFrancois L. Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire. Immunol Today. 1991; 12(12):436-438. (Biology). 2. Ledbetter JA, Herzenberg LA. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev. 1979; 47:63-90. (Biology). 3. Ledbetter JA, Rouse RV, Micklem HS, Herzenberg LA. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med. 1980; 152(2):280-295. (Biology). 4. MacDonald HR, Schreyer M, Howe RC, Bron C. Selective expression of CD8 alpha (Ly-2) subunit on activated thymic gamma/delta cells. Eur J Immunol. 1990; 20(4):927-930. (Biology). 5. Sydora BC, Brossay L, Hagenbaugh A, Kronenberg M, Cheroutre H. TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes. J Immunol. 1996; 156(11):4209-4216. (Biology). 6. Traver D, Akashi K, Manz M, et al. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science. 2000; 290(5499):2152-2154. (Biology). 7. Vremec D, Zorbas M, Scollay R, et al. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med. 1992; 176(1):47-58. (Biology). 8. Walker ID, Murray BJ, Hogarth PM, Kelso A, McKenzie IF. Comparison of thymic and peripheral T cell Ly-2/3 antigens. Eur J Immunol. 1984; 14(10):906-910. (Biology). 9. Wang J, Klein JR. Thymus-neuroendocrine interactions in extrathymic T cell development. Science. 1994; 265(5180):1860-1862. (Biology). 10. van Ewijk W, van Soest PL, van den Engh GJ. Fluorescence analysis and anatomic distribution of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200. J Immunol. 1981; 127(6):2594-2604. (Biology).

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