BD Pharmingen- Purified Mouse Anti-Human IKK- w- Control_BD Pharmingen
产品信息
抗原名称
IKKβ
克隆号
F18-1875
BD化合物表
- 描述数量/尺寸零件号EntrezGene ID
- Purified Mouse Anti-Human IKKβ50 µg (1 ea)51-8120GRN/A
- HeLa Control Lysate50 µg (1 ea)51-16516NN/A
应用
实验应用
Western blot (Routinely Tested), Immunoprecipitation (Tested During Development)
反应种属
Human (QC Testing)
目标/特异性
IKKβ
文献
文献
研发参考(11)
1. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997; 388(6642):548-554. (Biology).
2. Israël A. The IKK complex: an integrator of all signals that activate NF-kappaB. Trends Cell Biol. 2000; 10(4):129-133. (Biology).
3. Lee FS, Hagler J, Chen ZJ, Maniatis T. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell. 1997; 88(2):213-222. (Biology).
4. Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science. 1999; 284(5412):321-325. (Biology).
5. Li ZW, Chu W, Hu Y, et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med. 1999; 189(11):1839-1845. (Biology).
6. Ling L, Cao Z, Goeddel DV. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci U S A. 1998; 95(7):3792-3797. (Biology).
7. Malinin NL, Boldin MP, Kovalenko AV, Wallach D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 1997; 385(6616):540-544. (Biology).
8. Mercurio F, Zhu H, Murray BW, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997; 278(5339):860-866. (Biology).
9. Nakano H, Shindo M, Sakon S, et al. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A. 1998; 95(7):3537-3542. (Biology).
10. Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998; 395(6699):297-300. (Biology).
11. Tanaka M, Fuentes ME, Yamaguchi K, et al. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity. 1999; 10(4):421-429. (Biology).
参考图片
Western blot analysis of Ikkβ. Lysate from HeLa cells was probed with anti-Ikkβ (clone F18-1875, Cat. No. 51-8120GR) at concentrations of 0.25 (lane 1), 0.125 (lane 2), and 0.06 µg/ml (lane 3). Ikkβ is identified as a band of ~87 kDa.
Western blot analysis of Ikkβ. Lysate from HeLa cells was probed with anti-Ikkβ (clone F18-1875, Cat. No. 51-8120GR) at concentrations of 0.25 (lane 1), 0.125 (lane 2), and 0.06 µg/ml (lane 3). Ikkβ is identified as a band of ~87 kDa.
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