CD218b (IL-18 Receptor β)

Rat IgG2a, λ

Mouse sIL-1R7 fusion protein

The TC30-28E3 antibody specifically binds to the β subunit of the mouse Interleukin-18 Receptor complex (IL-18Rβ). The mouse IL-18R complex is expressed by T cells stimulated with IL-12 alone or cultured with antigen and IL-12 to induce Th1 cells. IL-18R is constitutively expressed by NK cells. Resting mouse T cells and Th2 cells do not express detectable levels of IL-18R. The mouse IL-18R complex consists of the IL-18α chain, also known as IL-1 Receptor related protein 1 (IL-1Rrp1 or IL-R5) and the IL-18Rβ chain also known as IL-1R accessory protein-like (IL-1RAcPL or IL-R7). The cell surface IL-18Rα chain binds IL-18 with low affinity. However its interaction with the IL-18Rβ chain confers high affinity binding for the ligand. The IL-18Rβ chain is not involved in ligand binding but is responsible for the transduction of biological signals. The immunogen used to generate the TC30-28E3 hybridoma was sIL-1R7 fusion protein.

The TC30-28E3 antibody specifically binds to the β subunit of the mouse Interleukin-18 Receptor complex (IL-18Rβ). The mouse IL-18R complex is expressed by T cells stimulated with IL-12 alone or cultured with antigen and IL-12 to induce Th1 cells. IL-18R is constitutively expressed by NK cells. Resting mouse T cells and Th2 cells do not express detectable levels of IL-18R. The mouse IL-18R complex consists of the IL-18α chain, also known as IL-1 Receptor related protein 1 (IL-1Rrp1 or IL-R5) and the IL-18Rβ chain also known as IL-1R accessory protein-like (IL-1RAcPL or IL-R7). The cell surface IL-18Rα chain binds IL-18 with low affinity. However its interaction with the IL-18Rβ chain confers high affinity binding for the ligand. The IL-18Rβ chain is not involved in ligand binding but is responsible for the transduction of biological signals. The immunogen used to generate the TC30-28E3 hybridoma was sIL-1R7 fusion protein.

Rat IgG2a, λ

TC30-28E3

1.0 mg/ml

Neutralization (Routinely Tested)

Mouse (QC Testing)

IL-1RAcPL, IL-R7

No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2µm sterile filtered. Endotoxin level is ≤0.01 EU/µg (≤0.001 ng/µg) of protein as determined by the LAL assay.

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