BD Pharmingen- Purified Anti-Human CD137_BD Pharmingen
产品信息
抗原名称
CD137
宿主
Mouse IgG1, κ
简单描述
Human 4-1BB, also known as CDw137, is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. Naïve T cells lack the 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. It has been reported that the expression of 4-1BB is restricted to primed CD4+ and CD8+ cells. When triggered by either 4-1BB ligand or antibody ligation, the 4-1BB molecule can act as a co-stimulator to induce T-cell activation and proliferation. In recent studies, 4-1BB has been emphasized for its effect on the development and survival of functionally active effector CD8 (+) T cells against tumors, virus infections, allogenic immune responses, and for potential therapeutic application.
商品描述
h41BB-M127
Human 4-1BB, also known as CDw137, is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. Naïve T cells lack the 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. It has been reported that the expression of 4-1BB is restricted to primed CD4+ and CD8+ cells. When triggered by either 4-1BB ligand or antibody ligation, the 4-1BB molecule can act as a co-stimulator to induce T-cell activation and proliferation. In recent studies, 4-1BB has been emphasized for its effect on the development and survival of functionally active effector CD8 (+) T cells against tumors, virus infections, allogenic immune responses, and for potential therapeutic application.
同种型
Mouse IgG1, κ
克隆号
克隆 h41BB-M127 (RUO)
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
ELISA Capture (Routinely Tested)
反应种属
Human (QC Testing)
目标/特异性
CD137 (4-1BB)
背景
别名
4-1BB, CDw137
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(4)
1. Kim YJ, Broxmeyer HE. Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells. J Hematother Stem Cell Res. 2001; 10(4):441-449. (Biology).
2. Melero I, Shuford WW, Newby SA, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med. 1997; 3(6):682-685. (Biology).
3. Michel J, Schwarz H. Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes. Cytokine. 2000; 12(6):742-746. (Clone-specific: (Co)-stimulation).
4. Vinay DS, Kwon BS. Role of 4-1BB in immune responses. Semin Immunol. 1998; 10(6):481-489. (Clone-specific: Activation).
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