BD Pharmingen- Purified Mouse Anti-Human CD328_BD Pharmingen
产品信息
抗原名称
CD328
宿主
Mouse IgG1, κ
免疫原
Recombinant Siglec-7
简单描述
The F023-420 monoclonal antibody specifically recognizes CD328 which is also known as sialic acid binding Ig like lectin 7 (Siglec-7). CD238 is an I-type lectin of approximately 65 kDa, expressed as a monomer on a major subset of NK cells and a subset of CD8+ cells. It is also expressed at moderate levels on monocytes and weakly on granulocytes. Siglecs (
s
ialic acid/
i
mmuno
g
lobulin/
lec
tin) are a family of I-type lectins that bind to sialic acids on the cell surface. They are a family of carbohydrate binding proteins within the immunoglobulin superfamily. Siglecs are integral membrane proteins with extracellular N-terminal, V-set Ig domains, followed by variable numbers of C2-set Ig domains.
商品描述
F023-420
The F023-420 monoclonal antibody specifically recognizes CD328 which is also known as sialic acid binding Ig like lectin 7 (Siglec-7). CD238 is an I-type lectin of approximately 65 kDa, expressed as a monomer on a major subset of NK cells and a subset of CD8+ cells. It is also expressed at moderate levels on monocytes and weakly on granulocytes. Siglecs (
s
ialic acid/
i
mmuno
g
lobulin/
lec
tin) are a family of I-type lectins that bind to sialic acids on the cell surface. They are a family of carbohydrate binding proteins within the immunoglobulin superfamily. Siglecs are integral membrane proteins with extracellular N-terminal, V-set Ig domains, followed by variable numbers of C2-set Ig domains.
同种型
Mouse IgG1, κ
克隆号
克隆 F023-420 (RUO)
浓度
0.5 mg/ml
产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested)
反应种属
Human (QC Testing)
目标/特异性
CD328 (Siglec-7)
背景
别名
Siglec-7; Siglec7; AIRM1; sialic acid binding Ig like lectin 7
制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(4)
1. Angata T, Hingorani R, Varki NM, Varki A. Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. J Biol Chem. 2001; 276(48):45128-45136. (Biology).
2. Crocker PR, Varki A. Siglecs, sialic acids and innate immunity. Trends Immunol. 2001; 22(6):337-342. (Biology).
3. Nicoll G, Ni J, Liu D, et al. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. J Biol Chem. 1999; 274(48):34089-34095. (Biology).
4. Powell LD, Varki A. I-type lectins. J Biol Chem. 1995; 270(24):14243-14246. (Biology).
参考图片
Profile of human Siglec-7 (clone F023-420) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
Profile of human Siglec-7 (clone F023-420) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
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