BD Pharmingen- Biotin Mouse Anti-Mouse IgG2a -b_BD Pharmingen
产品信息
宿主
Mouse BALB/c IgG3, κ
免疫原
Not Reported
简单描述
This antibody reacts specifically with mouse IgG2a of
Igh-C [b]
haplotype (e.g., C57BL/6, C57BL/10, NOD, SJL). It has been reported not to react with IgG2a of the
a, c, d, e, f, g, h, j, n, o,
or
p
haplotypes (e.g., A, AKR, BALB/c, C3H/He, C58, CBA, DBA/1, DBA/2, NZB, SWR). Molecular genetic analyses suggest that the Igh-1 [b] allele, which encodes IgG2a [b], is derived from a locus found in several wild mouse subspecies, but not domestic mice, which encodes the IgG2c isotype.
商品描述
5.7
This antibody reacts specifically with mouse IgG2a of
Igh-C [b]
haplotype (e.g., C57BL/6, C57BL/10, NOD, SJL). It has been reported not to react with IgG2a of the
a, c, d, e, f, g, h, j, n, o,
or
p
haplotypes (e.g., A, AKR, BALB/c, C3H/He, C58, CBA, DBA/1, DBA/2, NZB, SWR). Molecular genetic analyses suggest that the Igh-1 [b] allele, which encodes IgG2a [b], is derived from a locus found in several wild mouse subspecies, but not domestic mice, which encodes the IgG2c isotype.
同种型
Mouse BALB/c IgG3, κ
克隆号
克隆 5.7 (RUO)
浓度
0.5 mg/ml
产品详情
Biotin
Biotin is a ubiquitous co-factor (also known as Vitamin B7) that has many properties that make it extremely useful for molecular biology. Biotin has an extremely high affinity for the Avidin family of proteins (Kd = 10-15 M), making it the perfect tool to link two molecules. Biotin labeled antibodies can be combined with any number of Avidin-conjugated probes in order to customize an assay to a particular need. This is especially useful in the case of magnetic cell separation using streptavidin/magnetic bead conjugates, or in the case of flow cytometry using streptavidin/fluorophore conjugates.
应用
实验应用
ELISA Detection (Routinely Tested), Flow cytometry (Tested During Development)
反应种属
Mouse (QC Testing)
目标/特异性
IgG2a[b]
背景
别名
Igh-1 [b]; Igh-1; Igh-1a; Ighg2a; Immunoglobulin heavy constant gamma 2A
制备和贮存
存储溶液
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
保存方式
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
文献
文献
研发参考(4)
1. Huang CM, Parsons M, Oi VT, Huang HJ, Herzenberg LA. Genetic characterization of mouse immunoglobulin allotypic determinants (allotopes) defined by monoclonal antibodies. Immunogenetics. 1983; 18(4):311-321. (Biology).
2. Martin RM, Silva A, Lew AM. The Igh-1 sequence of the non-obese diabetic (NOD) mouse assigns it to the IgG2c isotype. Immunogenetics. 1997; 46(2):167-168. (Biology).
3. Morgado MG, Cam P, Gris-Liebe C, Cazenave PA, Jouvin-Marche E. Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes. EMBO J. 1989; 8(11):3245-3251. (Biology).
4. Parsons M, Oi VT, Huang CM, Herzenberg LA. Structural characterization of mouse immunoglobulin allotypic determinants (allotopes) defined by monoclonal antibodies. Immunogenetics. 1983; 18(4):323-334. (Biology).
参考图片
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