产品信息
抗原名称
p110δ ,p110γ ,p110β
商品描述
PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.
分子量
489.53
纯度
>98%
可溶性
DMSO 98 mg/mL (200.19 mM)
外观
Powder
In vitro(体外研究)
PIK-294 shows distinct patterns of isoform selectivity to inhibit different subsets of class I PI3K isoforms (p110β, p110δ, and p110γ) and exhibits low sensitivity to p110α with IC50 of 10 μM). The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity.
背景
别名
PIK294,PIK 294
分子式
C28H23N7O2
CAS号
900185-02-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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