产品信息
抗原名称
STAT6
商品描述
AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.
分子量
397.86
纯度
＞98%
可溶性
DMSO : ≥ 35 mg/mL (87.97 mM)
外观
white to beige powder
In vitro(体外研究)
AS1517499 inhibit IL-4-induced Th2 differentiation of mouse spleen T cells, but has no influence on Th1 differentiation induced by IL-12. AS1517499 is able to prevent the IL-4-activated STAT6-mediated increase of the clonogenic potential of primary PCa cells. At a dose of 300 nM, AS1517499 decreases the clonogenic potential of primary basal PCa cells.
In vivo(体内研究)
In vivo treatment with AS1517499 ameliorates the antigen-induced bronchial smooth muscle (BSM) hyperresponsiveness by inhibiting the RhoA up-regulation in BSMs and, at least in part, by reducing the IL-13 production in the airways in mice. AS1517499 reduces preventive effects of apoptotic cell instillation on bleomycin-induced lung fibrosis by suppressing PPARγ.
背景
别名
AS-1517499；AS 1517499
分子式
C20H20ClN5O2
CAS号
919486-40-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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