产品信息
抗原名称
KSR2
商品描述
APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK.
分子量
423.89
纯度
＞98%
可溶性
DMSO : 20 mg/mL (51.62 mM; Need ultrasonic)
外观
powder
In vitro(体外研究)
APS-2-79 functions as an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site. APS-2-79 is inactive when KSR was absent or when the KSR2(A690F) mutant was used for in vitro assays. APS-2-79 increases the potency of several MEK inhibitors specifically within Ras-mutant cell lines by antagonizing release of negative feedback signalling.
背景
别名
APS-2-79 HCl
分子式
C23H21N3O3·HCl
CAS号
2002381-31-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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