产品信息
抗原名称
mTOR ,cFMS ,FLT4 ,DNA-PK
商品描述
CC-223 is a potent, selective, and orally bioavailable <b>mTOR</b> inhibitor with <b>IC50</b> of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.
分子量
397.47
纯度
99%
可溶性
体外:
DMSO 79mg/mL(198.75mM)
Ethanol 79mg/mL(198.75mM)
Water <1mg/mL
DMSO 79mg/mL(198.75mM)
Ethanol 79mg/mL(198.75mM)
Water <1mg/mL
In vitro(体外研究)
In a panel of cell lines, CC-223 inhibits both mTORC1 (S6RP and 4EBP1) and mTORC2 markers with IC50 ranges of 27 to 184 nM for pS6RP, 120 to 1,050 nM for p4EBP1 and 11 to 150 nM for pAKT(S473), respectively. CC-223 also inhibits cell growth and induces apoptosis across a number of cancer cell lines.
In vivo(体内研究)
In PC-3 tumor-bearing mice, CC-223 (25 mg/kg, p.o.) inhibits both mTORC1 and mTORC2. CC-223 (25 mg/kg, p.o.) also results in tumor growth inhibition by 47% to 95% in xenograft models of prostate, glioma, breast, lung, and colon.
背景
分子式
C21H27N5O3
CAS号
1228013-30-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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