产品信息
抗原名称
HIF-1
商品描述
Chetomin is an inhibitor of <b>HIF-1</b> by weaken transcription of HIF-1,disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
分子量
710.87
纯度
95%
可溶性
DMSO ：100mg/mL(140.67mM)
Ethanol ：10mg/mL(14.06mM)
Ethanol ：10mg/mL(14.06mM)
外观
Off-white to fawn solid
In vitro(体外研究)
HIF-1 (hypoxia-inducible factors 1) is transcription factor which respond to changes of cellular environment oxygen. Chetomin selectively inhibits HIF-1 activities through disruption of the interaction of HIF-1 with its transcriptional coactivator p300. HIF-1 inhibition by chetomin effectively reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Chetomin attenuates the hypoxia-induced radioresistance of malignant glioma cell lines U251MG (DMF10: 1.35 and 1.18) and U343MG (DMF10: 1.78 and 1.48). Targeting of HIF-1 using chetomin abolishes the differentiation-inhibitory effect of hypoxia-inducible factor-1α.
In vivo(体内研究)
Administration of chetomin in combination with forskolin significantly suppresses malignant glioma growth in an in vivo xenograft model .Che-M(chetomin loaded micelles) dramatically inhibits embryonic angiogenesis, tumor-induced angiogenesis and tumor growth in zebrafish. In mouse model, Che-M suppresses tumor growth and prolongs the survival in the subcutaneous CT26 tumor model .
背景
别名
毛壳菌素
分子式
C31H30N6O6S4
CAS号
1403-36-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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