产品信息
抗原名称
ERK1,ERK2
商品描述
Ulixertinib (BVD-523, VRT752271) is a potent and reversible <b>ERK1/ERK2</b> inhibitor with <b>IC50</b> of <0.3 nM for ERK2. Phase 1.
分子量
433.33
纯度
≥98%
可溶性
DMSO : 100 mg/mL (230.77 mM; Need ultrasonic)
In vitro(体外研究)
In an A375 melanoma cell line containing a b-RAFV600E mutation, Ulixertinib reduces the levels of phosphorylated ERK2 (pERK) and of the phosphorylation of the downstream kinase RSK (pRSK) with IC50 of 4.1/0.14 μM, respectively. Ulixertinib also inhibits A375 cell proliferation with IC50 of 180 nM.
In vivo(体内研究)
In the pharmacokinetic study, the sensitivity and specificity of the assay are found to be sufficient for accurately characterizing the plasma pharmacokinetics of VRT752271 in Balb/C mice.
背景
分子式
C21H22Cl2N4O2
CAS号
869886-67-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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