产品信息
抗原名称
Smoothened
商品描述
BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.
分子量
473.57
纯度
>98%
可溶性
DMSO 95 mg/mL (200.6 mM)
外观
Powder
In vitro(体外研究)
BMS-833923 reduces hedgehog pathway activity, decreases cell proliferation and induces apoptosis via the intrinsic pathway in esophageal adenocarcinoma (EAC) cell lines. BMS-833923 dose-dependently affects canonical and prostate hedgehog signature gene transcription in vitro.
背景
别名
BMS 833923; BMS833923; XL-139; XL139; XL 139
分子式
C30H27N5O
CAS号
1059734-66-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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