产品信息
抗原名称
BTK
商品描述
AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk currently being evaluated in a Phase 1b clinical trial in relapsed.
分子量
423.44
纯度
>98%
可溶性
DMSO 85 mg/mL (200.73 mM)
外观
Powder
In vitro(体外研究)
AVL-292 exhibits dose-dependent inhibition of Btk with EC50 of 8 nM and downstream BCR signaling components in Ramos cells. AVL-292, by inhibiting BTK activities, further inhibits B cell proliferation with EC50 of 3 nM.
In vivo(体内研究)
In a collagen-induced arthritis mouse model, AVL-292 (3- 30 mg/kg, p.o.) dose-dependently inhibits the clinical signs of inflammatory disease, including reduction in joint and paw swelling and visible redness of the affected paws.
背景
别名
CC-292; AVL292; AVL-292; AVL 292;Spebrutinib
分子式
C22H22FN5O3
CAS号
1202757-89-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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