产品信息
抗原名称
c-Met
商品描述
INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase.
分子量
412.42
纯度
>98%
可溶性
DMSO 2 mg/mL (4.84 mM)
外观
Powder
In vitro(体外研究)
INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration.
In vivo(体内研究)
INCB28060 shows strong antitumor activity in c-MET-dependent mouse tumor models, even oral treatment of 0.03 mg/kg INCB28060 causes approximately 50% inhibition of c-MET-phosphorylation. Dose-dependent inhibition of tumor growth is observed in tumor-bearing mice.
背景
别名
INCB 28060; INCB-28060; INC280
分子式
C23H17FN6O
CAS号
1029712-80-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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