产品信息
抗原名称
CDK1/CyclinB；CDK2/CyclinA；CDK2/CyclinE； CDK5/p35；GSK-3β
商品描述
Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β).
分子量
327.2
纯度
>98%
可溶性
DMSO : ≥ 35 mg/mL (106.97 mM)
外观
Yellow-brown Powder
In vitro(体外研究)
Kenpaullone shows much less effect on c-src (IC50, 15 μM), casein kinase 2 (IC50, 20 μM), erk 1 (IC50, 20 μM), and erk 2 (IC50, 9 μM). Kenpaullone acts by competitive inhibition of ATP binding, and the apparent Ki is 2.5 μM. Kenpaullone can inhibit the growth of tumor cells in culture (mean GI50, 43 μM) and causes altered cell cycle progression most clearly revealed under conditions of recovery from serum starvation. Kenpaullone demonstrates a wide range of biological utility, extending from maintenance of pancreatic β cell survival and proliferation to the induction of apoptosis in cancer cells.
背景
别名
肯帕罗酮；克莱拉尼
分子式
C16H11BrN2O
CAS号
142273-20-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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