产品信息
抗原名称
Mps1
商品描述
MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.
分子量
407.51
纯度
>98%
可溶性
DMSO 62 mg/mL warmed (152.14 mM)
Ethanol 2 mg/mL warmed (4.9 mM)
Ethanol 2 mg/mL warmed (4.9 mM)
外观
Powder
In vitro(体外研究)
MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe.
In vivo(体内研究)
MPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) shows antitumor activity in colon cancer xenograft models.
背景
别名
MPI-0479605,MPI 0479605,MPI0479605
分子式
C22H29N7O
CAS号
1246529-32-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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