产品信息
抗原名称
EZH2 ,EZH1
商品描述
CPI-1205是一种有效的选择性组蛋白赖氨酸甲基转移酶EZH2的抑制剂，具有潜在的抗肿瘤活性。
分子量
518.57
纯度
98% min
可溶性
DMSO 100 mg/mL (192.83 mM)
Ethanol 100 mg/mL (192.83 mM)
Water slightly soluble or insoluble
Ethanol 100 mg/mL (192.83 mM)
Water slightly soluble or insoluble
In vitro(体外研究)
Treatment with EZH2 inhibitor CPI-1205 cause apoptosis in multiple myeloma and plasmacytoma cell models.
In vivo(体内研究)
CPI-1205 shows excellent oral bioavailability. It was well-tolerated for repeat dosing as demonstrated by the absence of significant body weight loss. CPI-1205 shows relatively high clearance in both rats and dogs (3.19 L/h/kg and 1.41 L/h/kg, respectively) but demonstrates good oral bioavailability in both species(44.6% F in rats and 46.2% F in dogs). CPI-1205 was well-tolerated in the 28-day GLP toxicology studies, and any findings were reversible over the recovery period.
背景
别名
CPI 1205, CPI1205
分子式
C27H33F3N4O3
CAS号
1621862-70-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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