产品信息
抗原名称
MMP-2 ,MMP-9
商品描述
SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.
分子量
306.4
纯度
>98%
可溶性
DMSO : 30.6 mg/mL (100 mM)
Ethanol : 6.1 mg/mL (20 mM)
Ethanol : 6.1 mg/mL (20 mM)
外观
Powder
In vitro(体外研究)
SB-3CT directly inhibits bone marrow endothelial cell invasion and tubule formation in Matrigel in vitro.
In vivo(体内研究)
In L-CI.5s T-cell lymphoma model, SB-3CT (5-50 mg/kg/d i.p.) potently inhibit liver metastasis and increases survival of mice. SB-3CT (50 mg/kg/d i.p.) inhibits human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model. In a mouse model of embolus-induced “permanent” focal cerebral ischemia, SB-3CT counteracts degradation of neuronal laminin, protects neurons from ischemic cell death, and ameliorates neurobehavioral outcomes after embolic MCA occlusion.
背景
别名
SB3CT
分子式
C15H14O3S2
CAS号
292605-14-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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