产品信息
抗原名称
ALK2 ,ALK1 ,ALK3 ,ALK4 ,ALK5
商品描述
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.
分子量
406.48
纯度
>98%
可溶性
DMSO : ≥ 30 mg/mL (73.80 mM)
外观
white to beige Powder
In vitro(体外研究)
In myofibroblast C2C12 cells, LDN-212854 exhibits greater selectivity for BMP6- versus BMP4-induced osteogenic differentiation.
In vivo(体内研究)
LDN-212854 (6 mg/kg, i.p.) effectively neutralize ALK2 signaling in vivo, and potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.
背景
分子式
C25H22N6
CAS号
1432597-26-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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