产品信息
抗原名称
ALK2
商品描述
DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.
分子量
380.44
纯度
>98%
可溶性
DMSO : 11.5 mg/mL (30.23 mM; Need ultrasonic and warming)
外观
light yellow to orange Powder
In vitro(体外研究)
DMH1 inhibits BMP signaling with IC50 of 100 nM, and selectively inhibits the BMP-induced Smad1/5/8 activation. DMH1 increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. In addition, DMH1 as a BMP inhibitor, significantly reduces NSCLC cell growth, migration and invasion.
In vivo(体内研究)
DMH1 dorsalizes the embryonic axis without disrupting the angiogenic process in Zebrafish embryos. In proepicardial explants, DMH1 results in the greatest inhibition of epithelial sheet migration. DMH1 (5 mg/kg i.p.)attenuates xenograft lung tumor growth in mice bearing A549 xenograft.
背景
别名
DMH 1；DMH-1
分子式
C24H20 N4O
CAS号
1206711-16-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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