产品信息
抗原名称
Mer ,Tyro3
商品描述
UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
分子量
440.58
纯度
>98%
可溶性
DMSO 2 mg/mL warmed (4.53 mM)
外观
Powder
In vitro(体外研究)
UNC2250 efficiently inhibits Mer phosphorylation in 697 B-ALL cells and Colo699 NSCLC cells. Moreover, UNC2250 also displays functional antitumor activity by reducing colony-forming potential in both rhabdoid tumor cells and NSCLC cells.
In vivo(体内研究)
According to in vivo PK experiment, UNC2250 has a moderate half-life, clearance, and volume of distribution as well as reasonable oral bioavailability and good solubility.
背景
别名
UNC 2250; UNC-2250,
分子式
C24H36N6O2
CAS号
1493694-70-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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