产品信息
抗原名称
(beta)-catenin
商品描述
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay.
分子量
318.42
纯度
>98%
可溶性
DMSO : ≥ 42 mg/mL (131.90 mM)
外观
Powder
In vitro(体外研究)
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
In vivo(体内研究)
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1.
背景
别名
WAY262611; WAY 262611
分子式
C20H22N4
CAS号
1123231-07-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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