产品信息
抗原名称
guanylate cyclase；Tau aggregation
商品描述
Methylene Blue is used as a dye in chromoendoscopy. It Inhibits <b>tau filament formation</b> with <b>IC50</b> of 1.9μM. Also it inhibits <b>soluble guanylyl cyclase</b>.
分子量
319.85
纯度
97%
可溶性
DMSO ：63mg/mLwarming(196.96mM)
Water ：63mg/mLwarming(196.96mM)
Ethanol ：10mg/mLwarming(31.26mM)
Water ：63mg/mLwarming(196.96mM)
Ethanol ：10mg/mLwarming(31.26mM)
In vitro(体外研究)
MB may inhibit the action of nitric oxide synthase itself and could also inactivate nitric oxide directly, possibly through the generation of superoxide anions. In addition to interfering with the nitric oxide–cyclic guanosine monophosphate pathway, MB has also been shown to directly activate calcium-dependent potassium channels and to enhance release of noradrenaline from intracellular stores.
In vivo(体内研究)
Methylene Blue acts by inhibiting guanylate cyclase, thus decreasing C-GMP and vascular smooth muscle relaxation. When injected intravenously, MB selectively accumulates in parathyroid glands, thereby facilitating the identification of these structures during surgery. Pharmacokinetic studies in rodents revealed that intravascular administration of MB leads to a rapid and extensive accumulation of this drug in the central nervous system (CNS).
背景
别名
亚甲兰；Basic Blue 9；Methylthioninium chloride；CI-52015
分子式
C16H18ClN3S
CAS号
61-73-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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