产品信息
抗原名称
Proton pump ,HIF-1α
商品描述
Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
分子量
405.35
纯度
98%
可溶性
DMSO : 75 mg/mL (185 mM)
Ethanol : 75 mg/mL (185 mM)
Water : 74 mg/mL (182.6 mM)
Ethanol : 75 mg/mL (185 mM)
Water : 74 mg/mL (182.6 mM)
外观
白色或类白色结晶性粉末
In vitro(体外研究)
pantoprazole (PPZ) inhibits tumor cells proliferation, inducs apoptosis and decreases the expression of HIF-1α protein. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitizing effect on cancer cells.
In vivo(体内研究)
After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show the resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumorigenesis and induces large-scale apoptosis of tumor cells.
背景
别名
泮托拉唑钠；SKF96022 sodium
分子式
C16H14F2N3NaO4S
CAS号
138786-67-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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