产品信息
抗原名称
LRRK2,LRRK2
商品描述
GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor
分子量
449.83
纯度
>98%
可溶性
DMSO 89 mg/mL (197.85 mM)
Ethanol 12 mg/mL warmed (26.67 mM)
Ethanol 12 mg/mL warmed (26.67 mM)
外观
Powder
In vitro(体外研究)
GNE-9605 is highly potent against LRRK2 in both biochemical (Ki = 2.0 nM) and cellular (IC50 = 19 nM) assays. In vitro human MDR1 permeability data, GNE-9605 exhibits excellent brain penetration in higher species.
In vivo(体内研究)
In vivo rat PK studies with GNE-9605 (1 mg/kg, p.o.) demonstrates a total plasma clearance of 26 mL/min/kg with excellent oral bioavailability (90%). In BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation, GNE-9605 (10 and 50 mg/kg, i.p.) inhibits in vivo LRRK2 Ser1292 autophosphorylation.
背景
别名
GNE-9605,GNE9605,GNE 9605
分子式
C17H20ClF4N7O
CAS号
1536200-31-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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