产品信息
抗原名称
glucokinase
商品描述
LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.
分子量
559.81
纯度
>98%
可溶性
DMSO 112 mg/mL (200.06 mM)
Ethanol 35 mg/mL (62.52 mM)
Ethanol 35 mg/mL (62.52 mM)
外观
Powder
In vitro(体外研究)
LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. LY2608204 also stimulates glucose metabolism in rat insulinoma INS1-E cells with EC50 of 579 nM.
In vivo(体内研究)
LY2608204 decreases plasma glucose in a dose-dependent manner at both fasted and postprandial glucose levels. A maximal lowering of glucose AUC versus the untreated control group is observed with the high dose (30 mg/kg) and represents a 42% decrease. Interpolation of the data show that a 20% glucose AUC decrease occurs at an average LY2608204 concentration of 99 ng/mL (179 nM) in plasma, corresponding to a 6.9 mg/kg LY2608204 dose. The in vivo blood brain barrier permeability of LY2608204 results in a mean brain/plasma ratio of 0.17 five minutes post-dose with a mean total brain level of 0.539 nmol/g.
背景
别名
LY-2608204; LY 2608204
分子式
C28H37N3O3S3
CAS号
1234703-40-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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