产品信息
抗原名称
p97
商品描述
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).
分子量
520.67
纯度
>98%
可溶性
DMSO 100 mg/mL (192.06 mM)
外观
Powder
In vitro(体外研究)
NMS-873 reduces p97 sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873, as a p97 inhibitor, produces antiproliferative activity in a variety of hematological and solid tumor lines. The mechanism study indicates that NMS-873 activates the unfolded protein response, interfers with autophagy and thus induces cancer cell death.
背景
别名
NMS873; NMS 873
分子式
C27H28N4O3S2
CAS号
1418013-75-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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