产品信息
抗原名称
ATGL
商品描述
Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM.
分子量
283.37
纯度
>98%
可溶性
DMSO : 52 mg/mL (183.5 mM)
Ethanol : 4 mg/mL (14.11 mM)
Ethanol : 4 mg/mL (14.11 mM)
外观
white to beige Powder
In vitro(体外研究)
Atglistatin inhibits lipolysis in cell and organ cultures by targeting ATGL with no cytotoxicity up to a concentration of 50 μM.
In vivo(体内研究)
In vivo, Atglistatin (i.p.) results in Dose and time-dependent inhibition of lipolysis. Oral treatment of Atglistatin causes a dose-dependent decrease in FA and glycerol of up to 50% and 62%, respectively, and also causes a strong reduction in plasma TG levels (43%). In addition, Atglistatin shows a distinct tissue distribution and primarily accumulates in liver and adipose tissue.
背景
别名
N‘-[4‘-(二甲基氨基)[1,1‘-联苯]-3-基]-N,N-二甲基脲
分子式
C17H21N3O
CAS号
1469924-27-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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